Low doses of THC (tetrahydrocannabinol) can protect the brain from neuroinflammation-induced cognitive damage and “might be used as an effective drug for the treatment of neuroinflammatory conditions, including neurodegenerative diseases”, according to a new study published in the Journal of Neuroscience Research.
“In our previous studies, we found that a single ultralow dose of tetrahydrocannabinol (THC; 0.002 mg/kg, three to four orders of magnitude lower than the conventional doses) protects the brain from different insults that cause cognitive deficits”, says the study’s researchers. “Because various insults may trigger a neuroinflammatory response that leads to secondary damage to the brain, the current study tested whether this extremely low dose of THC could protect the brain from inflammation-induced cognitive deficits.”
For the study; “Mice received a single injection of THC (0.002 mg/kg) 48 hr before or 1-7 days after treatment with lipopolysccharide (LPS; 10 mg/kg) and were examined with the object recognition test 3 weeks later.”
After conducting the study, researchers conclude; “Our results suggest that an ultralow dose of THC that lacks any psychotrophic activity protects the brain from neuroinflammation-induced cognitive damage and might be used as an effective drug for the treatment of neuroinflammatory conditions, including neurodegenerative diseases.”
The study, conducted by researchers at the The Adelson Center for the Biology of Addictive Diseases and The Mauerberger Chair in Neuropharmacology at Sackler Faculty of Medicine in Israel, can be found by clicking here.