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Cannabis Has Anti-cancer Effects

ScienceDaily (Apr. 1, 2009) — Guillermo Velasco and colleagues, at Complutense University, Spain, have provided evidence that suggests that cannabinoids such as the main active component of marijuana (THC) have anticancer effects on human brain cancer cells.

cannabis anti cancer effectsIn the study, THC was found to induce the death of various human brain cancer cell lines and primary cultured human brain cancer cells by a process known as autophagy.

Consistent with the in vitro data, administration of THC to mice with human tumors decreased tumor growth and induced the  tumor cells to undergo autophagy.  As analysis of tumors from two patients with recurrent glioblastoma multiforme (a highly aggressive brain tumor) receiving intracranial THC administration showed signs of autophagy, the authors suggest that cannabinoid administration may provide a new approach to targeting human cancers.

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.

1. Salazar et al. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI37948

Adapted from materials provided by Journal of Clinical Investigation, via EurekAlert!, a service of AAAS.

Source: www.sciencedaily.com

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